Homologous Superfamily

Retinal cGMP phosphodiesterase, gamma subunit superfamily (IPR037030)

Short name: PDE6_gamma_sf

Overlapping entries


Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This entry represents the inhibitory gamma subunit [PMID: 11900530], which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells [PMID: 11502744].

The gamma subunit is intrinsically disordered and its interaction with the alpha subunit involves the selection of preconfigured transient conformations [PMID: 18230733].

GO terms

Biological Process

GO:0007601 visual perception

Molecular Function

GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0030553 cGMP binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.