Homologous Superfamily

Ammonia/particulate methane monooxygenase, subunit A superfamily (IPR037001)

Short name: NH3/CH4_mOase_suA_sf


Ammonia monooxygenase and the particulate methane monooxygenase are both integral membrane proteins, occurring in ammonia oxidisers and methanotrophs respectively, which are thought to be evolutionarily related [PMID: 7590173]. These enzymes have a relatively wide substrate specificity and can catalyse the oxidation of a range of substrates including ammonia, methane, halogenated hydrocarbons and aromatic molecules [PMID: 12209257]. These enzymes are composed of 3 subunits - A (IPR003393), B (IPR006833) and C (IPR006980) - and contain various metal centres, including copper. Particulate methane monooxygenase from Methylococcus capsulatus str. Bath is an ABC homotrimer, which contains mononuclear and dinuclear copper metal centres, and a third metal centre containing a metal ion whose identity in vivo is not certain[PMID: 15674245].

The A subunit from Methylococcus capsulatus str. Bath resides primarily within the membrane and consists of 7 transmembrane helices and a beta-hairpin which interacts with the soluble region of the B subunit. A conserved glutamate residue is thought to contribute to a metal centre [PMID: 15674245].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.