Homologous Superfamily

Ski-like, DNA-binding domain superfamily (IPR037000)

Short name: Ski_DNA-bd_sf

Overlapping entries


The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation [PMID: 7999783]. It may play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli.

Ski is a multidomain protein that includes a domain bearing high sequence similarity with the retinal determination protein Dachshund [PMID: 15130471]. This conserved domain contains a DNA binding motif [PMID: 12057194].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.