Family

ABL interactor 2 (IPR036993)

Short name: ABI2

Overlapping homologous superfamilies

None.

Family relationships

  • ABI family (IPR028457)
    • ABL interactor 2 (IPR036993)

Description

Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for cytoskeletal reorganization [PMID: 11516653]. Abi1 and Abi2 play an important role in actin cytoskeleton dynamics through participation in several multiprotein complexes. They participate in the formation of the Abi/WAVE complex, which regulates Arp2/3-mediated actin filament nucleation and actin network assembly [PMID: 21482783, PMID: 11516653, PMID: 17101133].

Abi2 is a component of the WAVE1 complex. It localises to sites of actin polymerisation at the tips of lamellipodia and filopodia [PMID: 11516653]. Its structure has been solved [PMID: 21107423].

GO terms

Biological Process

GO:0008154 actin polymerization or depolymerization

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER