Homologous Superfamily

Metallocarboxypeptidase-like, propeptide (IPR036990)

Short name: M14A-like_propep

Overlapping entries


The peptidases are synthesised as inactive molecules, zymogens, with propeptides that must be removed by proteolytic cleavage to activate the enzyme. Structural studies of carboxypeptidases A and B reveal the propeptide to exist as a globular domain, followed by an extended alpha-helix; this shields the catalytic site, without specifically binding to it, while the substrate-binding site is blocked by making specific contacts [PMID: 7674922, PMID: 1548696].

This entry represents a propeptide associated with peptidases belonging to MEROPS peptidase family M14A. It is found in the carboxypeptidases A [PMID: 9384570] and B [PMID: 12162965], and in fungal putative metallocarboxypeptidase Ecm14.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.