Homologous Superfamily

Deoxyhypusine synthase superfamily (IPR036982)

Short name: Deoxyhypusine_synthase_sf

Description

Eukaryotic initiation factor 5A (eIF-5A), now considered to be an elongation factor (see IPR001884), contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DS, EC:2.5.1.46). The enzyme catalyses the following reaction:

Spermidine + [eIF-5A]-lysine = 1,3-diaminopropane + [eIF-5A]-deoxyhypusine

The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation [PMID: 9493264]. The structure is known for this enzyme in complex with its NAD+ cofactor, it is a tetramer of four identical subunits arranged with 222 symmetry where each subunit contains a Rossmann fold [PMID: 9493264].

GO terms

Biological Process

GO:0008612 peptidyl-lysine modification to peptidyl-hypusine

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D