Homologous Superfamily

Deoxyhypusine synthase superfamily (IPR036982)

Short name: Deoxyhypusine_synthase_sf

Overlapping entries


Eukaryotic initiation factor 5A (eIF-5A), now considered to be an elongation factor (see IPR001884), contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DS, EC: The enzyme catalyses the following reaction:

Spermidine + [eIF-5A]-lysine = 1,3-diaminopropane + [eIF-5A]-deoxyhypusine

The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation [PMID: 9493264]. The structure is known for this enzyme in complex with its NAD+ cofactor, it is a tetramer of four identical subunits arranged with 222 symmetry where each subunit contains a Rossmann fold [PMID: 9493264].

GO terms

Biological Process

GO:0008612 peptidyl-lysine modification to peptidyl-hypusine

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.