Homologous Superfamily

Diacylglycerol kinase (DAGK) superfamily (IPR036945)

Short name: DAGK_sf

Overlapping entries


Prokaryotic diacylglycerol kinase (DAGK) and undecaprenol kinase (UDPK) constitute a family of multispan membrane enzymes that are very small, lack relationships to any other family of proteins and exhibit an unusual structure. Escherichia coli DAGK plays an important role in recycling diacylglycerol produced as a by-product of biosynthesis of molecules located in the periplasmic space. UDPK seems to play an analogous role in Gram-positive bacteria, where it is essential for biofilm formation by the oral pathogen Streptococcus mutans [PMID: 22224599].

Diacylglycerol kinase (EC: (DAGK) is an enzyme that catalyses the formation of phosphatidic acid from diacylglycerol and ATP, an important step in phospholipid biosynthesis. In bacteria DAGK is very small (13 to 15 kD) membrane protein which seems to contain three transmembrane domains [PMID: 8071224].

GO terms

Biological Process

GO:0008610 lipid biosynthetic process

Molecular Function

GO:0016301 kinase activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.