Homologous Superfamily

Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily (IPR036939)

Short name: Cu2_ascorb_mOase_N_sf

Overlapping entries


Copper type II, ascorbate-dependent monooxygenases [PMID: 2792366] are a class of enzymes that requires copper as a cofactor and which uses ascorbate as an electron donor. This family contains two related enzymes, dopamine-beta-monooxygenase (EC: and peptidyl-glycine alpha-amidating monooxygenase (EC: There are a few regions of sequence similarities between these two enzymes, two of these regions contain clusters of conserved histidine residues which are most probably involved in binding copper.

This superfamily represents the central domain of the enzyme.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0005507 copper ion binding
GO:0004497 monooxygenase activity
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.