Homologous Superfamily

Thiol:disulfide interchange protein DsbD, N-terminal domain superfamily (IPR036929)

Short name: DsbDN_sf

Overlapping entries


Folding of secreted proteins within the periplasm of Escherichia coli requires the formation of disulfide bonds, a process that is dependent on the Dsb (disulfide bond) proteins. The reduction of Dsb proteins DsbC, DsbE, and DsbG occurs by transport of electrons from cytoplasmic thioredoxin to the C-terminal thioredoxin-like domain of DsbD (DsbDC). The N-terminal domain of DsbD (DsbDN) is capable of forming disulfides with oxidized DsbC, DsbE, or DsbG as well as with reduced DsbD [PMID: 12033924]. This entry represents the DsbDN superfamily. Structurally, this domain has an immunoglobulin-like beta-sandwich fold which consists of seven strands arranged in two sheets with a greek-key topology.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.