Homologous Superfamily

Haem-binding HasA superfamily (IPR036912)

Short name: HasA_haem-bd_sf

Overlapping entries


Free iron is limited in vertebrate hosts, thus an alternative to siderophores has been developed by pathogenic bacteria to access host iron bound in protein complexes. HasA is a secreted haemophore that has the ability to obtain iron from haemoglobin. Once bound to HasA, the haem is shuttled to the receptor HasR, which releases the haem into the bacterium [PMID: 10360351].

The HasA domain structure has a beta-alpha-beta(6)-alpha(2) fold with antiparallel sheet.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.