Homologous Superfamily

RNA polymerase Rpb7-like, N-terminal domain superfamily (IPR036898)

Short name: RNA_pol_Rpb7-like_N_sf

Overlapping entries


The eukaryotic RNA polymerase subunits RPB4 and RPB7 form a heterodimer that reversibly associates with the RNA polymerase II core. Archaeal cells contain a single RNAP made up of about 12 subunits, displaying considerable homology to the eukaryotic RNAPII subunits. The RPB4 and RPB7 homologues are called subunits F and E, respectively, and have been shown to form a stable heterodimer. While the RPB7 homologue is reasonably well conserved, the similarity between the eukaryotic RPB4 and the archaeal F subunit is barely detectable [PMID: 11741548].

This entry represents the N-terminal, heterodimerisation domain superfamily of RPB7 and homologues. This domain has a beta-alpha-beta(2) fold arranged in two layers (alpha/beta) with antiparallel beta-sheet.

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

GO:0003899 DNA-directed 5'-3' RNA polymerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.