Homologous Superfamily

UVR domain superfamily (IPR036876)

Short name: UVR_dom_sf

Overlapping entries


During the process of Escherichia coli nucleotide excision repair, DNA damage recognition and processing are achieved by the action of the uvrA, uvrB, and uvrC gene products [PMID: 8466476]. UvrB and UvrC share a common domain of around 35 amino acids, the so called UVR domain. This domain in UvrB can interact with the homologous domain in UvrC throughout a putative coiled coil structure. This interaction is important for the incision of the damaged strand [PMID: 8530482].

A conserved region similar to the UVR domain is also found in the ATP-binding subunit of bacterial and chloroplastic Clp ATPases [PMID: 15554981], which suggest that the UVR domain is not only involved in the interaction between uvrB and uvrC.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.