Homologous Superfamily

Replication modulator SeqA, C-terminal DNA-binding domain superfamily (IPR036835)

Short name: SeqA_DNA-bd_C_sf

Overlapping entries


The binding of the negative modulator of initiation of replication (SeqA) protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation [PMID: 11457824]. SeqA tetramers are able to aggregate or multimerize in a reversible, concentration-dependent manner [PMID: 11457824]. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor [PMID: 11442835].

The C-terminal domain binds DNA, binding to hemimethylated GATC sequences at oriC [PMID: 12379844, PMID: 14704346]. The structure of the C-terminal domain consists of seven alpha-helices and three-stranded beta-sheet.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.