Homologous Superfamily

Translation initiation factor 3 (IF-3), C-terminal domain superfamily (IPR036788)

Short name: T_IF-3_C_sf

Overlapping entries


Initiation factor 3 (IF-3) (gene infC) is one of the three factors required for the initiation of protein biosynthesis in bacteria. IF-3 is thought to function as a fidelity factor during the assembly of the ternary initiation complex which consist of the 30S ribosomal subunit, the initiator tRNA and the messenger RNA. IF-3 is a basic protein that binds to the 30S ribosomal subunit [PMID: 8405963]. The chloroplast initiation factor IF-3(chl) is a protein that enhances the poly(A,U,G)-dependent binding of the initiator tRNA to chloroplast ribosomal 30s subunits in which the central section is evolutionary related to the sequence of bacterial IF-3 [PMID: 8144528].

The C-terminal domain of IF-3 has a beta-alpha-beta-alpha-beta(2) fold arranged into two layers with mixed sheet and strand 4 antiparallel to the rest.

GO terms

Biological Process

GO:0006413 translational initiation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.