Homologous Superfamily

Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily (IPR036784)

Short name: AK/P_DHK_N_sf

Overlapping entries


Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. Regulating the activity of the branched-chain alpha-ketoacid dehydrogenase (BCDH) complex is the primary means by which these processes are coordinated. BCDH kinase regulates BCDH by phosphorylation, thereby inactivating it when synthesis is required.

Pyruvate dehydrogenase kinase inhibits the pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. It is also involved in telomere maintenance.

This entry is associated with IPR003594 which is found towards the C terminus.

The N-terminal domain of the alpha-ketoacid dehydrogenase kinase has a bromodomain-like fold, which consists of four helices arranged in bundle with minor mirror variant of up-and-down topology.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.