Homologous Superfamily

Fe(II) trafficking protein YggX superfamily (IPR036766)

Short name: Fe_traffick_prot_YggX_sf

Overlapping entries


The protein superfamily represented by this entry, YggX, serves to protect Fe-S clusters from oxidative damage [PMID: 11416172]. The effect is two-fold: proteins that rely on Fe-S clusters do not become inactivated, and the release of free iron and hydrogen peroxide--a DNA damaging agent--is prevented. These observations are consistent with the hypothesis that YggX chelates free iron, and recent experiments show that YggX can indeed bind Fe(II) in vitro and in vivo [PMID: 12670952]. Furthermore, YggX has a positive effect on the action of at least one Fe(II)-responsive protein. The combined actions of YggX is reminiscent of iron trafficking proteins [PMID: 12033438], and YggX is therefore proposed to play a role in Fe(II) trafficking [PMID: 12670952]. In Escherichia coli, YggX was shown to be under the transcriptional control of the redox-sensing SoxRS system [PMID: 14594836].

Structurally, YggX has a beta(2)-alpha(3) fold and contains a zinc-less 'zinc finger'-like fold.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005506 iron ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.