Homologous Superfamily

Putative dsDNA mimic superfamily (IPR036763)

Short name: Put_dsDNA_mimic_sf

Overlapping entries


This entry represents hypothetical proteins such as HI1450, which is believed to act as a putative dsDNA mimic. HI1450 is an acidic protein with a core structure consisting of alpha(2)-beta(4), where the alpha-helices are packed against the side of an anti-parallel 4-stranded beta meander. As such, it has some similarity to the dsDNA mimics uracil-DNA glycosylase inhibitor and nuclease A inhibitor (NuiA), including the distribution of surface charges and the position of the hydrophobic cavity [PMID: 14747986]. DNA mimics act to inhibit or regulate dsDNA-binding proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.