Homologous Superfamily

CART, C-terminal domain superfamily (IPR036722)

Short name: CART_C_sf

Overlapping entries


The cocaine and amphetamine regulated transcript (CART) is a brain-localised peptide that acts as a satiety factor in appetite regulation. CART was found to inhibit both normal and starvation-induced feeding, and completely blocks the feeding response induced by neuropeptide Y. CART is regulated by leptin in the hypothalamus, and can be transcriptionally induced after cocaine or amphetamine administration [PMID: 9590691]. CART has also been suggested to activate ERK1 through interaction with a specific G-protein coupled receptor [PMID: 15908120]. Posttranslational processing of CART produces an N-terminal CART peptide and a C-terminal CART peptide. The C-terminal CART peptide has been isolated from the hypothalamus, nucleus accumbens, and the anterior pituitary lobe in rats. C-terminal CART is the biologically active part of the molecule affecting food intake. The structure of C-terminal CART consists of a disulphide-bound fold containing a beta-hairpin and two adjacent disulphide bridges [PMID: 11478874].

GO terms

Biological Process

GO:0007186 G protein-coupled receptor signaling pathway
GO:0000186 activation of MAPKK activity
GO:0008343 adult feeding behavior
GO:0032099 negative regulation of appetite

Molecular Function

GO:0005184 neuropeptide hormone activity

Cellular Component

GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.