Homologous Superfamily

Phosphotransferase system, sorbose subfamily IIB component superfamily (IPR036667)

Short name: PTS_IIB_sorbose-sp_sf

Overlapping entries


Bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains [PMID: 11532441]. The Man family is unique in several respects among PTS permease families:

  • It is the only PTS family in which members possess a IID protein.
  • It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue.
  • Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars.

The mannose permease of Escherichia coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. The active site histidine receives a phosphate group from the IIA subunit and transfers it to the substrate [PMID: 10393270]. This entry represents the IIB components of this family of PTS transporters [PMID: 12662934]. The structure of this component has three layers (alpha/beta/alpha) with parallel beta-sheet of six strands.

GO terms

Biological Process

GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system

Molecular Function

GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.