Homologous Superfamily

SOS response associated peptidase-like (IPR036590)

Short name: SRAP-like

Overlapping entries


The SOS response associated peptidase (SRAP) superfamily functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. The human SRAP member (Q96FZ2) has been shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine. It was predicted to be a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes [PMID: 23945014].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.