Homologous Superfamily

Phosphatase 2C, C-terminal domain superfamily (IPR036580)

Short name: PP2C_C_sf

Overlapping entries


Protein phosphatase 2C (PP2C, also known as Protein phosphatase 1) is involved in regulating cellular responses to stress in various eukaryotes. It consists of two domains: an N-terminal catalytic domain and a C-terminal domain characteristic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices, one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain [PMID: 9003755].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0000287 magnesium ion binding
GO:0030145 manganese ion binding
GO:0004721 phosphoprotein phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.