Homologous Superfamily

Ribosome hibernation promotion factor-like (IPR036567)

Short name: RHF-like

Overlapping entries


This superfamily consists of ribosome hibernation promoting factors (RHFs). RHF promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes during the stationary phase [PMID: 18174192].

This superfamily also includes RaiA (ribosome-associated inhibitor A, also known as Protein Y (PY), YfiA, and SpotY). This is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site [PMID: 15502846]. RaiA is also thought to counteract miscoding at the A site thus reducing translation errors [PMID: 15219834]. The RaiA fold structurally resembles the double-stranded RNA-binding domain (dsRBD) [PMID: 12392550] with a beta-alpha-beta(3)-alpha fold arranged into two layers with mixed sheet, where strand 3 is antiparallel to the rest.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.