Homologous Superfamily

Molybdopterin biosynthesis MoaE subunit superfamily (IPR036563)

Short name: MoaE_sf

Overlapping entries


Members of the MoaE family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits [PMID: 8514782, PMID: 12504674, PMID: 11913130, PMID: 10746556, PMID: 15709772, PMID: 12571227, PMID: 12571226].

Structurally, the MoaE subunit has a beta-BETA-alpha-beta-BETA-beta-alpha fold and contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids.

GO terms

Biological Process

GO:0006777 Mo-molybdopterin cofactor biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.