Homologous Superfamily

Core-binding factor, beta subunit superfamily (IPR036552)

Short name: CBF_bsu_sf

Overlapping entries


Core binding factor (CBF) is a heterodimeric transcription factor essential for genetic regulation of hematopoiesis and osteogenesis. The beta subunit binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including Murine leukemia virus, Polyomavirus enhancer, T-cell receptor enhancers etc. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold [PMID: 10404215]. This superfamily also includes the Drosophila melanogaster brother and big brother proteins, which regulate the DNA-binding properties of Runt.

The CBF structure has a close barrel fold with meander and is capped at both ends by alpha-helices.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003713 transcription coactivator activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.