Homologous Superfamily

Anti-Sigma Factor A superfamily (IPR036486)

Short name: AsiA_sf

Overlapping entries


Anti-sigma factor A is a transcriptional inhibitor that inhibits sigma 70-directed transcription by weakening its interaction with the core of the host's RNA polymerase. It is an all-helical protein, composed of six helical segments and intervening loops and turns, as well as a helix-turn-helix DNA binding motif, although neither free anti-sigma factor nor anti-sigma factor bound to sigma-70 has been shown to interact directly with DNA. In solution, the protein forms a symmetric dimer of small (10.59 kDa) protomers, which are composed of helix and coil regions and are devoid of beta-strand/sheet secondary structural elements [PMID: 11830637].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.