Homologous Superfamily

Heat-stable enterotoxin B superfamily (IPR036479)

Short name: STb_sf

Overlapping entries

Description

Members of this superfamily assume a helical secondary structure, with two alpha helices forming a disulphide cross-linked alpha-helical hairpin. The disulphide bonds are crucial for the toxic activity of the protein, and are required for maintenance of the tertiary structure, and subsequent interaction with the particulate form of guanylate cyclase, increasing cyclic GMP levels within the host intestinal epithelial cells [PMID: 8528070].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY