Formyl transferase, N-terminal domain superfamily (IPR036477)
Short name: Formyl_transf_N_sf
- Formyl transferase, N-terminal (IPR002376)
- Phosphoribosylglycinamide formyltransferase (IPR004607)
- Formyltetrahydrofolate deformylase (IPR004810)
- Methionyl-tRNA formyltransferase (IPR005794)
- [NiFe]-hydrogenase maturation factor, HypX/HoxX type (IPR009188)
- 10-formyltetrahydrofolate dehydrogenase (IPR011407)
- Bifunctional polymyxin resistance protein, ArnA (IPR021168)
A number of formyl transferases belong to this group. Methionyl-tRNA formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl minoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-ormylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP. Formyltetrahydrofolate dehydrogenase produces formate from formyl-tetrahydrofolate. This is the N-terminal domain of these enzymes and is found upstream of the C-terminal domain (IPR005793).
The trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase catalyses the second, third and fifth steps in de novo purine biosynthesis. The glycinamide ribonucleotide transformylase belongs to this group.
The formyl transferase N-terminal domain structure has a three layers (alpha/beta/alpha) fold, with a mixed beta-sheet of seven strands where strand 6 is antiparallel to the rest.
- SSF53328 (SSF53328)