Pathways & interactions
SpoA-like superfamily (IPR036429)
Short name: SpoA-like_sf
- Flagellar motor switch FliN/Type III secretion HrcQb (IPR001172)
- Surface presentation of antigen (SpoA) (IPR001543)
- Flagellar motor switch protein FliM (IPR001689)
- Type III secretion system outer membrane, SpaO (IPR003283)
- Flagellar motor switch FliN (IPR012826)
- Type III secretion system apparatus protein YscQ/HrcQ/SpaO (IPR013385)
Proteins of the surface presentation of antigen (SpoA) group are involved in a secretory pathway responsible for the surface presentation of invasion plasmid antigen needed for the entry of Salmonella and other species into mammalian cells [PMID: 1447979, PMID: 8885278].They could play a role in preserving the translocation competence of the IPA antigens and are required for secretion of the three IPA proteins [PMID: 1312536].
The SpoA structure is composed of a segment-swapped dimer forming two identical conjoint barrels fold and is topologically similar to the FMN-binding split barrel.
The C-terminal region of flagellar motor switch proteins FliN and FliM is also included in this entry.