Homologous Superfamily

Pterin 4 alpha carbinolamine dehydratase superfamily (IPR036428)

Short name: PCD_sf

Overlapping entries


Pterin 4 alpha carbinolamine dehydratase is also known as DCoH. DCoH is the dimerisation cofactor of hepatocyte nuclear factor 1 (HNF-1) that functions as both a transcriptional coactivator and a pterin dehydratase [PMID: 8897596]. X-ray crystallographic studies have shown that the ligand binds at four sites per tetrameric enzyme, with little apparent conformational change in the protein.

DCoH has a beta(2)-alpha-beta(2)-alpha fold arranged in two alpha/beta layers.

GO terms

Biological Process

GO:0006729 tetrahydrobiopterin biosynthetic process

Molecular Function

GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.