Homologous Superfamily

Elongation factor Ts, dimerisation domain superfamily (IPR036402)

Short name: EF-Ts_dimer_sf

Overlapping entries


Elongation factor EF1B (also known as EF-Ts or EF-1beta/gamma/delta) is a nucleotide exchange factor that is required to regenerate EF1A from its inactive form (EF1A-GDP) to its active form (EF1A-GTP). EF1A is then ready to interact with a new aminoacyl-tRNA to begin the cycle again. EF1B is more complex in eukaryotes than in bacteria, and can consist of three subunits: EF1B-alpha (or EF-1beta), EF1B-gamma (or EF-1gamma) and EF1B-beta (or EF-1delta) [PMID: 12762045].

This superfamily describes a beta(2)-alpha(n)-beta two layers (alpha-beta) fold domain of EF-Tu (EF1A). In E. coli and mitochondrial Ts there are two subdomains of this fold [PMID: 8596629, PMID: 15557323].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.