Homologous Superfamily

Guanylin superfamily (IPR036382)

Short name: Guanylin_sf

Overlapping entries


This entry represents the guanylin superfamily. Its members include guanylate cyclase activator 2A and 2B. They are endogenous activators of intestinal guanylate cyclases.

Guanylin, a 15-amino-acid peptide, is an endogenous ligand of the intestinal receptor guanylate cyclase-C, known as STaR [PMID: 7713512, PMID: 1409606]. Upon receptor binding, guanylin increases the intracellular concentration of cGMP, it induces chloride secretion and decreases intestinal fluid absorption, ultimately causing diarrhoea [PMID: 1346555]. The peptide stimulates the enzyme through the same receptor binding region as the heat-stable enterotoxins [PMID: 1409606].

Guanylin structure has a beta(2)-alpha(3)-beta fold and two layers (alpha/beta) with an antiparallel sheet topology.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0030250 guanylate cyclase activator activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.