Homologous Superfamily

Replication terminator Tus, domain 1 (IPR036381)

Short name: Tus_dom1

Overlapping entries


Bacterial DNA replication terminus site-binding proteins (also known as Tus or Ter-binding proteins) are required for the termination of DNA replication and function by binding to DNA replication terminator sequences, thus preventing the passage of replication forks [PMID: 2687269]. The termination efficiency is affected by the affinity of a particular protein for the terminator sequence.

Tus protein folds into two domains divided by a central basic cleft [PMID: 8857533]. This superfamily describes the N-terminal 3-layer sandwich domain.

GO terms

Biological Process

GO:0006274 DNA replication termination

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.