Homologous Superfamily

High potential iron-sulphur protein superfamily (IPR036369)

Short name: HIPIP_sf

Overlapping entries


High potential iron-sulphur proteins (HiPIP) [PMID: 1917989, PMID: 1317860] are a specific class of high-redox potential 4Fe-4S ferredoxins that functions in anaerobic electron transport and which occurs commonly in purple photosynthetic bacteria and in other bacteria, such as Paracoccus denitrificans and Thiobacillus ferrooxidans [PMID: 14562962].

HiPIPs seem to react by oxidation of [4Fe-4S]2+ to [4Fe-4S]3+

The HiPIPs are small proteins which show significant variation in their sequences, their sizes (from 63 to 85 amino acids), and in their oxidation- reduction potentials. As shown in the following schematic representation the iron-sulphur cluster is bound by four conserved cysteine residues.

                           [4Fe-4S cluster]
                           | |       |     |

'C': conserved cysteine involved in the binding of the iron-sulphur cluster.

GO terms

Biological Process

GO:0019646 aerobic electron transport chain

Molecular Function

GO:0009055 electron transfer activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.