Homologous Superfamily

Activator of Hsp90 ATPase, Aha1 (IPR036338)

Short name: Aha1

Overlapping entries

Description

Aha1 is a co-chaperone that binds to the chaperone Hsp90 stimulating its ATPase activity. Aha1 adopts a secondary structure consisting of an N-terminal alpha-helix leading into a four-stranded meandering antiparallel beta-sheet, followed by a C-terminal alpha-helix. The two alpha helices are packed together, with the beta-sheet curving around them. The N-terminal domain of Aha1 interacts with Hsp90 and stimulates its ATPase activity [PMID: 15039704].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
GENE3D