Homologous Superfamily

5'-3' exonuclease, C-terminal domain superfamily (IPR036279)

Short name: 5-3_exonuclease_C_sf

Overlapping entries


This entry represents the C-terminal domain of 5' to 3' exonucleases. The 5'-3' exonucleases are conserved in organisms as diverse as bacteriophage and mammals. It adopts a SAM fold consisting of 4-5 helices packed into a bundle of two orthogonally packed alpha-hairpins. This domain is involved in interactions with DNA and proteins. 5' to 3' exonucleases that contain this domain include:

  • Bacteriophage T4 RNase H, which has sequence similarity to the RAD2 family of eukaryotic proteins [PMID: 8674116].
  • 5' to 3' exonuclease domain of DNA polymerase Taq, which is homologous to Escherichia coli DNA polymerase I (pol I) [PMID: 7637814, PMID: 10666572].
  • Bacteriophage T5 5'-exonuclease, which are structure-specific endonucleases [PMID: 9874768].
  • Flap endonuclease-1 (Fen-1 nuclease), a structure specific nuclease that is an essential enzyme for eukaryotic DNA replication and repair [PMID: 9699635].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.