Homologous Superfamily

RuvA, C-terminal domain superfamily (IPR036267)

Short name: RuvA_C_sf

Overlapping entries


In prokaryotes, RuvA, RuvB, and RuvC process the universal DNA intermediate of homologous recombination, termed Holliday junction. The tetrameric DNA helicase RuvA specifically binds to the Holliday junction and facilitates the isomerization of the junction from the stacked folded configuration to the square-planar structure [PMID: 12408833]. In the RuvA tetramer, each subunit consists of three domains, I, II and III, where I and II form the major core that is responsible for Holliday junction binding and base pair rearrangements of Holliday junction executed at the crossover point, whereas domain III regulates branch migration through direct contact with RuvB.

The domain represents the C-terminal domain III of RuvA. This domain plays a significant role in the ATP-dependent branch migration of the hetero-duplex through direct contact with RuvB [PMID: 10890893]. Within the Holliday junction, this domain makes no interaction with the DNA.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.