Homologous Superfamily

MmgE/PrpD superfamily (IPR036148)

Short name: MmgE/PrpD_sf

Overlapping entries

Description

MmgE/PrpD superfamily members include 2-methylcitrate dehydratase (PrpD; EC:4.2.1.79) and citrate/2-methylcitrate dehydratase MmgE. PrpD is required for propionate catabolism, catalysing the third step of the 2-methylcitric acid cycle [PMID: 11782506]. This enzyme consists of two domains: a large domain with an all-helical fold and a smaller domain that folds into an alpha beta domain [PMID: 16934291]. Cis-aconitic acid decarboxylase (CAD) shares high identity with proteins of the MmgE/PrpD family. CAD is essential for itaconic acid production in Aspergillus terreus [PMID: 18584171].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016829 lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY