Pathways & interactions
Class XVIII myosin, motor domain (IPR036064)
Short name: MYSc_Myo18
Overlapping homologous superfamilies
- P-loop containing nucleoside triphosphate hydrolase (IPR027417)
- Kinesin motor domain superfamily (IPR036961)
- Myosin head, motor domain (IPR001609)
- Class XVIII myosin, motor domain (IPR036064)
Many members of myosin class XVIII contain an N-terminal PDZ domain which is commonly found in proteins establishing molecular complexes. Mammals express a second isoform, Myo18B, that lacks the PDZ domain [PMID: 12761286]. They also contain a motor domain which does not exhibit ATPase activity, suggesting that these myosins function as an actin tether protein [PMID: 15835906, PMID: 21498886]. They also have two IQ domains that probably bind light chains or related calmodulins and a C-terminal tail with two sections of coiled-coil domains, which are thought to mediate homodimerization [PMID: 15582604]. Myo18A has been implicated in stromal cell differentiation [PMID: 10733906] and Myo18B in tumor suppression [PMID: 12209013].
This entry represents the motor domain.
- cd01386 (MYSc_Myo18)