Class XVI myosin, motor domain (IPR036042)

Short name: MYSc_Myo16

Overlapping homologous superfamilies

Domain relationships


Type XVI myosin (Myo16) is also known as neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3/NYAP3. Myo16 is thought to play a regulatory role in cell cycle progression and has been implicated in schizophrenia [PMID: 23596177, PMID: 24141571]. Class XVI myosins are characterized by an N-terminal ankyrin repeat domain thought to bind protein phosphatase 1 catalytic subunits 1alpha/PPP1CA and 1gamma/PPP1CC [PMID: 17029291]. Myo16 interacts with phosphoinositide 3-kinase and the components of the WAVE1 complex [PMID: 21946561]. The catalytic (head) domain may not act as a molecular motor as sequence analysis of the ATP-binding site predicted reduced ATPase activity [PMID: 17029291].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.