Homologous Superfamily

Crustacean CHH/MIH/GIH neurohormone superfamily (IPR035957)

Short name: Crust_neurohorm_sf

Overlapping entries


Hyperglycemic hormone, which controls blood sugar levels, is an abundant peptide in the sinus glands of isopods and decapods [PMID: 2792364, PMID: 8436119]. The peptide is a potent secretagogue, releasing digestive enzymes from the hepatopancreas. It may act as a stress hormone. The peptide contains around 70 amino acid residues, and includes six cysteine residues involved in disulphide bond formation [PMID: 8436119]. The sequences show a high degree of similarity to the American lobster molt-inhibiting hormone [PMID: 2169734], which also shows hyper-glycemic hormone activity.

Sequence analysis reveals at least 2 discrete sequence families, characterized by distinctive N- and C-terminal signatures: broadly, the families represent separate groups of the crustacean hyperglycemic-like hormones and the molt-inhibiting-like hormones. The positions of five of the six cysteine residues are conserved between these families, the first Cys being displaced by one residue position.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.