Homologous Superfamily

Crustacean CHH/MIH/GIH neurohormone superfamily (IPR035957)

Short name: Crust_neurohorm_sf


Hyperglycemic hormone, which controls blood sugar levels, is an abundant peptide in the sinus glands of isopods and decapods [PMID: 2792364, PMID: 8436119]. The peptide is a potent secretagogue, releasing digestive enzymes from the hepatopancreas. It may act as a stress hormone. The peptide contains around 70 amino acid residues, and includes 6 cysteine residues involved in disulphide bond formation [PMID: 8436119]. The sequences show a high degree of similarity to the American lobster molt-inhibiting hormone [PMID: 2169734], which also shows hyper- glycemic hormone activity.

Sequence analysis reveals at least 2 discrete sequence families, characterised by distinctive N- and C-terminal signatures: broadly, the families represent separate groups of the crustacean hyperglycemic-like hormones and the molt-inhibiting-like hormones. The positions of 5 of the 6 cysteine residues are conserved between these families, the first Cys being displaced by one residue position.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.