Homologous Superfamily

CoaB-like superfamily (IPR035929)

Short name: CoaB-like_sf

Overlapping entries


CoaB adopts a 3-layer alpha/beta/alpha fold with mixed beta-sheets, which topologically resembles a combination of Rossmann-like and ribokinase-like folds. This structural domain can be found in human phosphopantothenoylcysteine (PPC) synthetase [PMID: 12906824] and CoaB from the Escherichia coli coenzyme A bifunctional protein CoaBC [PMID: 15530362]. The structure of these proteins predicts a ping pong mechanism with initial formation of an acyladenylate intermediate, followed by release of pyrophosphate and attack by cysteine to form the final products PPC and AMP.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.