Homologous Superfamily

RPB5-like RNA polymerase subunit superfamily (IPR035913)

Short name: RPB5-like_sf

Overlapping entries


This entry represents a two-layer alpha/beta fold, with a core structure of beta/alpha/beta/alpha/beta(2) found in prokaryotic subunit H and the C terminus of eukaryotic RPB5.

Prokaryotes contain a single DNA-dependent RNA polymerase (RNAP; EC: that is responsible for the transcription of all genes, while eukaryotes have three classes of RNAPs (I-III) that transcribe different sets of genes. Each class of RNA polymerase is an assemblage of ten to twelve different polypeptides. Certain subunits of RNAPs, including RPB5 (POLR2E in mammals), are common to all three eukaryotic polymerases. RPB5 plays a role in the transcription activation process. Eukaryotic RPB5 has a bipartite structure consisting of a unique N-terminal region (IPR005571), plus a C-terminal region that is structurally homologous to the prokaryotic RPB5 homologue, subunit H (gene rpoH) [PMID: 10841538, PMID: 10191143, PMID: 1729711, PMID: 10841537].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.