Homologous Superfamily

MurE/MurF, N-terminal (IPR035911)

Short name: MurE/MurF_N

Description

The MurF protein contains three domains. The N-terminal domain consists of a small alpha/beta fold and contacts the larger central domain across a broad hydrophobic interface. The central domain and the C-terminal domain adopt mononucleotide and dinucleotide (Rossmann) folds, respectively, and are connected by a short linker peptide that is poorly ordered in the crystal [PMID: 16322581].

This superfamily represents the N-terminal domain of the MurE/F proteins. They are ligases involved in the formation of UDP-N-acetylmuramyl-pentapeptide [PMID: 16322581] and have been considered as antibacterial targets [PMID: 24755374].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY