Homologous Superfamily

7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK superfamily (IPR035907)

Short name: Hppk_sf

Overlapping entries


7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase (EC: (HPPK) catalyses the attachment of pyrophosphate to 6-hydroxymethyl-7,8-dihydropterin to form 6-hydroxymethyl-7,8-dihydropteridine pyrophosphate. This is the first step in a three-step pathway leading to 7,8 dihydrofolate. Bacterial HPPK (gene folK or sulD) [PMID: 1325970] is a protein of 160 to 270 amino acids. In the lower eukaryote Pneumocystis carinii, HPPK is the central domain of a multifunctional folate synthesis enzyme (gene fas) [PMID: 1313386].

The structure of HPPK consists of an alpha/beta sandwich with antiparallel beta sheets.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.