SH2D2A, SH2 domain (IPR035884)

Short name: SH2D2A_SH2

Overlapping homologous superfamilies

Domain relationships

  • SH2 domain (IPR000980)
    • SH2D2A, SH2 domain (IPR035884)


This entry includes the single SH2 domain of SH2D2A. SH2D2A interacts with and modulates Lck activity [PMID: 16839418].

In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [PMID: 19926274, PMID: 19273114, PMID: 9551546].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.