Domain

BMX, SH2 domain (IPR035875)

Short name: BMX_SH2

Domain relationships

  • SH2 domain (IPR000980)
    • BMX, SH2 domain (IPR035875)

Description

Cytoplasmic tyrosine-protein kinase BMX (bone marrow tyrosine kinase gene on chromosome X, also known as ETK) is a non-receptor tyrosine kinase (EC:2.7.10.2). It plays central but diverse modulator roles in various signalling processes involved in the regulation of actin reorganisation, cell migration, cell proliferation and survival, cell adhesion, and apoptosis [PMID: 9520419, PMID: 23716717, PMID: 15355990]. It has a role in inflammation, cardiovascular disease, and cancer [PMID: 22449076]. It is activated downstream of phosphatidylinositol-3 kinase (PI3K) and the kinase Src [PMID: 23716717].

This entry represents the SH2 domain of BMX.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD