Tyrosine-protein kinase Lyn, SH2 domain (IPR035852)

Short name: Lyn_SH2

Overlapping homologous superfamilies

Domain relationships

  • SH2 domain (IPR000980)
    • Tyrosine-protein kinase Lyn, SH2 domain (IPR035852)


Lyn is a member of the Src non-receptor type tyrosine kinase family. It plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance [PMID: 7687428, PMID: 10748115]. It also mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils [PMID: 11435302, PMID: 14726379, PMID: 15795233]. Lyn plays an essential role in the transmission of signals through phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based inhibitory motifs (ITIM) in regulatory proteins [PMID: 10748115, PMID: 7594458].

This entry represents the SH2 domain of Lyn.

The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs [PMID: 28347651].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.