Ras GTPase-activating protein 1, N-terminal SH2 domain (IPR035841)

Short name: RasGAP_N_SH2

Overlapping homologous superfamilies

Domain relationships

  • SH2 domain (IPR000980)
    • Ras GTPase-activating protein 1, N-terminal SH2 domain (IPR035841)


Ras GTPase-activating protein 1 (also known as p120-RasGAP) is an inhibitory regulator of the Ras-cyclic AMP pathway [PMID: 8360177, PMID: 11389730]. Its C-terminal catalytic domain promotes GTP hydrolysis and plays a key role in the regulation of Ras-GTP bound [PMID: 19022332]. Its N-terminal part contains two SH2, SH3, PH (pleckstrin homology) and CaLB/C2 (calcium-dependent phospholipid-binding domain) domains, which allow various functions such as anti-/pro-apoptosis, proliferation and cell migration [PMID: 19022332].

Alternative splicing results in two isoforms. The shorter isoform which lacks the N-terminal hydrophobic region, has the same activity, and is expressed in placental tissues. In general the longer isoform contains two SH2 domains, an SH3 domain, a pleckstrin homology (PH) domain, and a calcium-dependent phospholipid-binding C2 domain. The C terminus contains the catalytic domain of RasGap which catalyzes the activation of Ras by hydrolyzing GTP-bound active Ras into an inactive GDP-bound form of Ras [PMID: 8955277].

This entry represents the N-terminal SH2 domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.