Domain

Dynamin-binding protein, third N-terminal SH3 domain (IPR035819)

Short name: DNMBP_SH3_N3

Overlapping homologous superfamilies

Domain relationships

  • SH3 domain (IPR001452)
    • Dynamin-binding protein, third N-terminal SH3 domain (IPR035819)

Description

Dynamin-binding protein (DNMBP, also known as Tuba) is a scaffold protein that links dynamin with actin-regulating proteins. It binds a variety of actin regulatory proteins, including N-WASP, CR16, WAVE1, WIRE, PIR121, NAP1, and Ena/VASP proteins, via a C-terminal SH3 domain [PMID: 14506234]. It plays a critical role in ciliogenesis and nephrogenesis, most likely via Cdc42 activation [PMID: 26895965].

The four N-terminal SH3 domains of DNMBP binds the GTPase dynamin, which plays an important role in the fission of endocytic vesicles [PMID: 16740596]. This entry represents the third N-terminal SH3 domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD