Domain

Procollagen C-endopeptidase enhancer, NTR domain (IPR035814)

Short name: NTR_PCOLCE

Domain relationships

Description

Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which has been suggested to possess inhibitory functions towards specific serine proteases but not towards metzincins, which are inhibited by the related TIMPs [PMID: 12670942].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD